منابع مشابه
Grapefruits and drugs: when is statistically significant clinically significant?
Editorial Lown et al. (1) report a significant advance in describing a new mechanism by which ingested nutrients may change exposure to drug therapy. Grapefruit juice was reported to increase plasma concentrations of felodipine and nifedipine when the drug was concurrently administered with grapefruit juice (2). The potential clinical importance of such an interaction was noted when cyclosporin...
متن کاملThe Difference between "Significant" and "Not Significant" Is Not Itself Statistically Significant
It is common to summarize statistical comparisons by declarations of statistical significance or non-significance. Here we discuss one problem with such declarations, namely that changes in statistical significance are often not themselves statistically significant. By this, we are not merely making the commonplace observation that any particular threshold is arbitrary—for example, only a small...
متن کاملNot significant but important.
Armstrong and colleagues report the result of a large Phase IIb randomized trial evaluating the effectiveness of a preparation of the Bowman Birk Inhibitor compared with an oral placebo in reversing the extent of oral leukoplakia as measured visually by pathology or a battery of intermediate end points. In this editorial, we review the report of this negative clinical trials result to highlight...
متن کاملSignificant drug interactions in dermatology
Systemic drugs have been used widely in the treatment of many skin diseases. Although dermatologists are familiar with the guidelines of selecting appropriate patients and prescribing systemic drugs, their knowledge about the side effects and significant interactions of systemic drugs used in dermatology is more limited. So a short review on important drug interactions seems to be useful. Some ...
متن کاملAre Nonsignificant Differences Really Not Significant?
Many researchers and reviewers hesitate to publish data when treatments are not “significantly” different. Most of us were taught to use a particular probability value (usually 5% or 1%) as a critical value to test hypotheses. The term “significant” has come to be synonymous with the phrase “significant at the 5% level.” Using relatively conservative critical values prevents readers from evalua...
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ژورنال
عنوان ژورنال: BMJ
سال: 1977
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6078.47-b